How Multiplexing Can Support Vaccine Development

xMAP® Technology supported the development of HPV vaccines, continues to provide key results in after-market studies

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Vaccine development is traditionally a complex and lengthy process. It requires a clear and in-depth understanding of the variants of a given disease-causing organism and their modes of pathogenesis, as well as the antigens they express. Successful efforts require a high-quality assay to detect all relevant variants in a timely manner in order to understand immunogenicity, among other critical factors.

It’s no secret that conventional enzyme-linked immunosorbent assays (ELISAs) are time and labor-intensive. For vaccine development, ELISAs simply cannot provide the throughput needed. Thankfully, xMAP® bead-based multiplexing technology offers a flexible and customizable platform to support both gene and protein expression assays. And unlike traditional technologies that can only measure one or a few biomarkers, researchers have the ability to easily scale the number of biomarkers measured—from 1 to 500 analytes—and the ability to customize assays for genotyping, protein expression profiling, gene expression profiling, and more.

Supporting vaccine development when and how it’s needed

A noteworthy example of how scientists have used xMAP Technology in vaccine development comes from the development of human papilloma virus (HPV) vaccines. More than a dozen HPV genotypes are associated with cervical cancer, necessitating a highly robust multiplex assay for the vaccine development process.

Two of the three globally licensed HPV vaccines—Gardasil®, a quadrivalent vaccine (4vHPV), and ® Technology (2021)” href=”/?wpdmdl=49089″>The Development of HPV Vaccines and the Contributions of Luminex xMAP Technology (2021)

  • The Role of Multiplexed Assays in Vaccine Development (2016)

    • Although the vaccines have long since been approved, xMAP multiplex assays continue to power studies examining long-term vaccine safety and efficacy, along with the worldwide impact of vaccination against HPV-related diseases. To learn more about how xMAP Technology can be used for vaccine development and more, check out the xMAP Cookbook!

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    For Research Use Only. Not for use in diagnostic procedures.

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